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KMID : 0923620230230010011
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Immune Network
2023 Volume.23 No. 1 p.11 ~ p.11
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Roles of Virtual Memory T Cells in Diseases
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Seok Joon
Cho Sung-Dong
Seo Seong-Jun
Park Su-Hyung
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Abstract
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Memory T cells that mediate fast and effective protection against reinfections are usually generated upon recognition on foreign Ags. However, a “memory-like” T-cell population, termed virtual memory T (TVM) cells that acquire a memory phenotype in the absence of foreign Ag, has been reported. Although, like innate cells, TVM cells reportedly play a role in first-line defense to bacterial or viral infections, their protective or pathological roles in immune-related diseases are largely unknown. In this review, we discuss the current understanding of TVM cells, focusing on their distinct characteristics, immunological properties, and roles in various immune-related diseases, such as infections and cancers.
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KEYWORD
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Virtual memory T cells, Infectious disease, Cancer
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